CBD

Anxiety: CBD as an Anxiety Treatment

KEY TAKEAWAYS:

  • Preclinical evidence strongly supports the potential of CBD as a treatment for anxiety 
  • In dogs, anxiety is responsible for depression, aggressiveness, restlessness and destructive and compulsive behaviors; it also impacts dogs’ quality of life in a significant and negative way
  • Cats have similar anxiety-related behaviors, with restlessness, trembling, aggression and decreased appetite being the most worrying problems. Isolation and anti-social attitudes are also common
  • 68.75% of the studies reviewed demonstrated the anxiolytic effects of CBD
  • CBD reduced experimentally-induced anxiety in healthy subjects and reduced anxiety in patients with social anxiety disorders (SAD)
  • Systemically administered CBD reduced acute increases in heart rate and blood pressure produced by states of heightened anxiety
  • CBD blocked reconsolidation of unpleasant memories in rats and enhanced extinction of fear memories in healthy humans
  • Human experimental studies put into evidence CBD’s excellent safety profile and minimal sedative effects
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Osteoarthritis: Safety and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs

KEY TAKEAWAYS:

  • During CBD treatment, dogs’ pain decreased with pain scores dropping from 21 to 14 (0-50 scale)
  • Use of CBD oil result in a 12% increase in dogs’ activity 
  • No side effects were reported by owners.  
  • These clinic results suggest that the use of 2 mg/kg CBD twice a day can increase the comfort and activity of dogs suffering from osteoarthritis 
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Inflammation: Anti-Inflammatory Effect of CBD on Canine Models of Inflammation

KEY TAKEAWAYS:

  • TNF-α is a proinflammatory molecule with increased expression and present in high pathological levels in canine atopic dermatitis
  • IL-6 (proinflammatory molecule) production is boosted in atopic dermatitis and its blockage can help improving this disease
  • Both TNF-α and IL-6 are associated with the pathogenesis of arthritis in dogs 
  • CBD reduced the secretion of TNF-α and IL-6 (molecules that drive the inflammatory response) in an ex vivo model of inflammation in canine blood cells
  • The TNF-α to IL-10 (pro-inflammatory molecule) ratio is a marker of the balance between key pro- and anti-inflammatory levels
  • Treatment with CBD restored the TNF-α to IL-10 ratio to a healthy balance 
  • CBD also reduced NF-κB activation (NF-κB is a regulator of the inflammatory response and of many pro-inflammatory cytokines)
  • Finally, administration of CBD to the inflamed cells resulted in a lower COX-2 (which is upregulated in inflammation) expression 
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Skin: CBD Modulates the Regulation of Inflammatory Genes Related to Canine Atopic Dermatits

KEY TAKEAWAYS:

  • Canine atopic dermatitis (AD) is a multifactorial allergic disease that affects up to 27% of dogs and is associated with immune dysfunction and abnormal skin barrier
  • Due to elevated costs and side effects of traditional medication, natural treatments are constantly being developed
  • Cannabidiol was able to downregulate key actors involved in the development and progression of this dermatological disease
  • Treatment with CBD + polyphenols showed an ability to revert the overexpression of canine AD key inflammatory genes
  • This study’s results provide groundwork for CBD application in sustained drug therapy or relapse prevention in atopic dermatitis
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Grooming: Hair Regrowth after Treatment with Topical CBD

KEY TAKEAWAYS:

  • The endocannabinoid system participates in skin equilibrium via CB1 and CB2 and TRPV receptors
  • Pre-clinical studies illustrate evidence of the hair regrowth benefits of antagonizing the CB1 receptors and over stimulating TRPV1 with CBD
  • CBD has also been shown to result in hair elongation and to maintain the hair follicle in the growing phase of the hair cycle
  • The study showed a 93.5% increase in nonvellus (new) hair after six months of treatment with topical CBD
  • No side effects were reported 
  • Growth of new hair it’s a way of reviving and replacing the damaged hair in your dog's fur
  • New hair is healthier, shinier and softer than old damaged hair, since it hasn't been in contact with the harmful stimuli of the environment 
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