Candid Summaries on CBD Studies
KEY TAKEAWAYS:
- Preclinical evidence strongly supports the potential of CBD as a treatment for anxiety
- In dogs, anxiety is responsible for depression, aggressiveness, restlessness and destructive and compulsive behaviors; it also impacts dogs’ quality of life in a significant and negative way
- Cats have similar anxiety-related behaviors, with restlessness, trembling, aggression and decreased appetite being the most worrying problems. Isolation and anti-social attitudes are also common
- 68.75% of the studies reviewed demonstrated the anxiolytic effects of CBD
- CBD reduced experimentally-induced anxiety in healthy subjects and reduced anxiety in patients with social anxiety disorders (SAD)
- Systemically administered CBD reduced acute increases in heart rate and blood pressure produced by states of heightened anxiety
- CBD blocked reconsolidation of unpleasant memories in rats and enhanced extinction of fear memories in healthy humans
- Human experimental studies put into evidence CBD’s excellent safety profile and minimal sedative effects
KEY TAKEAWAYS:
- During CBD treatment, dogs’ pain decreased with pain scores dropping from 21 to 14 (0-50 scale)
- Use of CBD oil result in a 12% increase in dogs’ activity
- No side effects were reported by owners.
- These clinic results suggest that the use of 2 mg/kg CBD twice a day can increase the comfort and activity of dogs suffering from osteoarthritis
KEY TAKEAWAYS:
- TNF-α is a proinflammatory molecule with increased expression and present in high pathological levels in canine atopic dermatitis
- IL-6 (proinflammatory molecule) production is boosted in atopic dermatitis and its blockage can help improving this disease
- Both TNF-α and IL-6 are associated with the pathogenesis of arthritis in dogs
- CBD reduced the secretion of TNF-α and IL-6 (molecules that drive the inflammatory response) in an ex vivo model of inflammation in canine blood cells
- The TNF-α to IL-10 (pro-inflammatory molecule) ratio is a marker of the balance between key pro- and anti-inflammatory levels
- Treatment with CBD restored the TNF-α to IL-10 ratio to a healthy balance
- CBD also reduced NF-κB activation (NF-κB is a regulator of the inflammatory response and of many pro-inflammatory cytokines)
- Finally, administration of CBD to the inflamed cells resulted in a lower COX-2 (which is upregulated in inflammation) expression
KEY TAKEAWAYS:
- Canine atopic dermatitis (AD) is a multifactorial allergic disease that affects up to 27% of dogs and is associated with immune dysfunction and abnormal skin barrier
- Due to elevated costs and side effects of traditional medication, natural treatments are constantly being developed
- Cannabidiol was able to downregulate key actors involved in the development and progression of this dermatological disease
- Treatment with CBD + polyphenols showed an ability to revert the overexpression of canine AD key inflammatory genes
- This study’s results provide groundwork for CBD application in sustained drug therapy or relapse prevention in atopic dermatitis
KEY TAKEAWAYS:
- The endocannabinoid system participates in skin equilibrium via CB1 and CB2 and TRPV receptors
- Pre-clinical studies illustrate evidence of the hair regrowth benefits of antagonizing the CB1 receptors and over stimulating TRPV1 with CBD
- CBD has also been shown to result in hair elongation and to maintain the hair follicle in the growing phase of the hair cycle
- The study showed a 93.5% increase in nonvellus (new) hair after six months of treatment with topical CBD
- No side effects were reported
- Growth of new hair it’s a way of reviving and replacing the damaged hair in your dog's fur
- New hair is healthier, shinier and softer than old damaged hair, since it hasn't been in contact with the harmful stimuli of the environment