Candid Summaries on CBD Studies

Osteoarthritis: Safety and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs

KEY TAKEAWAYS:

  • During CBD treatment, dogs’ pain decreased with pain scores dropping from 21 to 14 (0-50 scale)
  • Use of CBD oil result in a 12% increase in dogs’ activity 
  • No side effects were reported by owners.  
  • These clinic results suggest that the use of 2 mg/kg CBD twice a day can increase the comfort and activity of dogs suffering from osteoarthritis 
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Inflammation: Anti-Inflammatory Effect of CBD on Canine Models of Inflammation

KEY TAKEAWAYS:

  • TNF-α is a proinflammatory molecule with increased expression and present in high pathological levels in canine atopic dermatitis
  • IL-6 (proinflammatory molecule) production is boosted in atopic dermatitis and its blockage can help improving this disease
  • Both TNF-α and IL-6 are associated with the pathogenesis of arthritis in dogs 
  • CBD reduced the secretion of TNF-α and IL-6 (molecules that drive the inflammatory response) in an ex vivo model of inflammation in canine blood cells
  • The TNF-α to IL-10 (pro-inflammatory molecule) ratio is a marker of the balance between key pro- and anti-inflammatory levels
  • Treatment with CBD restored the TNF-α to IL-10 ratio to a healthy balance 
  • CBD also reduced NF-κB activation (NF-κB is a regulator of the inflammatory response and of many pro-inflammatory cytokines)
  • Finally, administration of CBD to the inflamed cells resulted in a lower COX-2 (which is upregulated in inflammation) expression 
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Osteoarthritis: Daily CBD Treatment to Reduce Canine Osteoarthritis Pain

KEY TAKEAWAYS:

  • Joint destruction in arthritis is driven by a series of inflammatory molecules, of which TNF-α is a major player
  • CBD induced a 97% reduction in the secretion of TNF-α in human cells
  • Influx of immune cells was reduced by more than 80% after topical CBD application, whereas TNF-α production was reduced by 50%.
  • Cannabidiol treatment significantly reduced the development of edema 
  • When injected into mice models, CBD caused an increase of anti-inflammatory molecules
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Osteoarthritis: Daily use of CBD for the Treatment of Canine Osteoarthritis Pain

KEY TAKEAWAYS:

  • 50 mg/day of CBD or 20 mg/day of liposomal CBD significantly reduced pain in dogs suffering from osteoarthritis
  • Packaging CBD within a liposome (delivery method) forms liposomal CBD and improves CBD’s bioavailability and absorption 
  • Movement indexes (standing, walking and running) were all improved after administration of both 50mg/day CBD and 20 mg/day liposomal CBD
  • Dog’s quality of life increased after CBD treatment
  • The study supports the safety and therapeutic potential of CBD for relieving arthritic pain and improving dog’s activity levels
  • No detrimental impact of CBD administration was reported
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Arthritis: Topical CBD use Reduces Inflammation and Pain-Related Behaviours Linked to Arthritis

KEY TAKEAWAYS:

  • Topical CBD proved to be an effective symptomatic, anti-inflammatory and anti-hyperalgesic treatment in arthritis
  • The subjects didn’t suffer any alteration in their activity levels or motor abilities.
  • A dose of 6.2mg/day of CBD significantly reduced swelling and synovial thickness
  • Transdermal CBD use improved pain, reducing the median score from 4 to 1.5 (0-5 scale)
  • Only after 2 days of CBD treatment, there was a significant improvement of heat hypersensitivity, which persisted throughout the experiment
  • Pro-inflammatory activity dropped as low as non-pathological levels after using CBD
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