Candid Summaries on CBD Studies

Osteoarthritis: Safety and Clinical Efficacy of Cannabidiol Treatment in Osteoarthritic Dogs

KEY TAKEAWAYS:

  • During CBD treatment, dogs’ pain decreased with pain scores dropping from 21 to 14 (0-50 scale)
  • Use of CBD oil result in a 12% increase in dogs’ activity 
  • No side effects were reported by owners.  
  • These clinic results suggest that the use of 2 mg/kg CBD twice a day can increase the comfort and activity of dogs suffering from osteoarthritis 
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Safety: Assessing the Safety of CBD in Healthy Dogs and Cats

KEY TAKEAWAYS:

  • This study brings to light the safety profile of CBD for both dogs and cats
  • CBD administration had no effect on food intake and body weight
  • No abnormal physical examinations, changes in behavior or organ dysfunction were detected after CBD administration in both dogs and cats
  • The administration of 4mg/kg of CBD daily to dogs and cats was well tolerated and not harmful 
  • CBD consumption by healthy dogs and cats did not alter blood analysis nor serum chemistry, supporting the secure and harmless profile of CBD 
  • Once again, this study provides foundation for the therapeutic use of CBD, since its properties have been vastly demonstrated and its safety evaluated
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Safety: Evaluating the Safety of Escalating Doses of CBD in Healthy Dogs

KEY TAKEAWAYS:

  • CBD oil administration had little effect on food intake and physical activity 
  • There was no difference in the adverse effect profile of CBD oil when compared to its control group
  • Administration of CBD oil up to a dose of 62mg/kg per day resulted in mild side effects only and these side effects were also detected in the corresponding placebo group
  • No moderate or clinically significant adverse effects were reported after  administration of CBD oil up to 62mg/kg daily
  • The study provides novel data that separates the safety and tolerability of dose escalation of oil formulations predominant in CBD, THC, or CBD + THC (1.5:1) 
  • There was a clear distinction in the safety profile of the CBD oil when compared to THC or CBD+THC oil, with CBD oil being the most well tolerated
  • The study supports the safe and tolerable profile of CBD oil even when administered up to 62mg/kg daily, which is considered a much higher dose than would be anticipated for clinical use
  • Normally recommended doses range from 0.5 to 8mg/kg
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Safety: Daily Oral Administration of CBD for 28 days in Healthy Dogs was Well Tolerated

KEY TAKEAWAYS:

  • Repeated CBD administration was well tolerated by dogs and no clinically relevant changes were observed related to the administration of any dose of CBD
  • Veterinary examinations revealed no clinically important abnormal findings
  • No observable differences between groups were detected in motor activity, ophthalmologic examinations, systolic arterial blood pressure (SAP), ECG and complete blood count (CBC) analysis 
  • All adverse effects were mild and self-limiting, required no intervention, and occurred across all treatment groups, including the placebo group
  • There was a greater frequency in side effects in the 12mg/kg group with hypersalivation being the most common one
  • The most notable change was the increase in serum ALP (liver enzyme) activity; these increases began to decrease after 2 weeks of treatment and not all dogs developed this change, suggesting that such increase may not be a hallmark of CBD administration but an adaptive response. The dogs that had higher ALP activity didn´t show any sign of hepatocellular degeneration indicating it is an adaptive rather than adverse response to drug exposure
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