Candid Summaries on CBD Studies

Safety: Daily Oral Administration of CBD for 28 days in Healthy Dogs was Well Tolerated

KEY TAKEAWAYS:

  • Repeated CBD administration was well tolerated by dogs and no clinically relevant changes were observed related to the administration of any dose of CBD
  • Veterinary examinations revealed no clinically important abnormal findings
  • No observable differences between groups were detected in motor activity, ophthalmologic examinations, systolic arterial blood pressure (SAP), ECG and complete blood count (CBC) analysis 
  • All adverse effects were mild and self-limiting, required no intervention, and occurred across all treatment groups, including the placebo group
  • There was a greater frequency in side effects in the 12mg/kg group with hypersalivation being the most common one
  • The most notable change was the increase in serum ALP (liver enzyme) activity; these increases began to decrease after 2 weeks of treatment and not all dogs developed this change, suggesting that such increase may not be a hallmark of CBD administration but an adaptive response. The dogs that had higher ALP activity didn´t show any sign of hepatocellular degeneration indicating it is an adaptive rather than adverse response to drug exposure
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Hemp Seed: Benefits of Adding Hemp Seed Oil to a Dog's Diet

KEY TAKEAWAYS:

  • n-6 and n-3 polyunsaturated fatty acids (PUFA) are essential and extremely important for the well-being and healthy development of dogs
  • Apart from its direct benefits, the presence of n-3 PUFA in the diet allows obtaining other benefits such as anti-inflammatory. 
  • Linolenic (n-6) and α-linolenic (n-3) acid cannot be produced by dogs and are therefore fundamental in a dog’s diet
  • The study showed that the hempseed cake supplement had a higher crude protein and fiber content than the compared animal lipid source 
  • The hempseed supplement showed a healthier fatty acid profile, with a higher concentration of PUVA, linolenic and α-linolenic acid and in a ratio ideal for dogs’ health and optimal for reduction of certain diseases, like cancer and sudden cardiac death 
  • After 1 month of diet supplementation with hempseed cake, dogs experienced a reduction in liver and renal markers 
  • Improvement of other hematological parameters, such as cholesterol, after the hempseed diet, confirmed that the addition of hempseed cake is safe for dogs to consume
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Cancer: Enhacing the Efficacy of Cancer Treatment with CBD

KEY TAKEAWAYS:

  • Previous findings report CBD’s ability to inhibit tumor invasion and cancer metastasis
  • 50% of dogs over 10 years of age have cancer and 20% of cats will develop cancer in their lifetime
  • Superior tumor cell killing was achieved with CBD than with 4 Gy (unit of radiation dose) of RT alone
  • Results support a greater effectiveness in killing tumor cells when combining CBD and radiotherapy (RT)
  • CBD use in combination with RT increased the survival rates of the studied mice
  • There is a clear demonstration of a bigger survival rate of CBD-treated mice comparing with the control group (no treatment)
  • In situ (in the exact local) delivery of CBD with smart biomaterials allows bigger concentrations of CBD to reach its target
  • CBD treatment occasioned an 80% survival rate (vs 50% in the control group) in mice with tumors, whereas the use of smart biomaterials loaded with CBD resulted in a 100% survival rates 
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Osteoarthritis: Daily CBD Treatment to Reduce Canine Osteoarthritis Pain

KEY TAKEAWAYS:

  • Joint destruction in arthritis is driven by a series of inflammatory molecules, of which TNF-α is a major player
  • CBD induced a 97% reduction in the secretion of TNF-α in human cells
  • Influx of immune cells was reduced by more than 80% after topical CBD application, whereas TNF-α production was reduced by 50%.
  • Cannabidiol treatment significantly reduced the development of edema 
  • When injected into mice models, CBD caused an increase of anti-inflammatory molecules
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