KEY TAKEAWAYS:

• Preclinical evidence strongly supports the potential of CBD as a treatment for anxiety 
• In dogs, anxiety is responsible for depression, aggressiveness, restlessness and destructive and compulsive behaviors; it also impacts dogs’ quality of life in a significant and negative way
• Cats have similar anxiety-related behaviors, with restlessness, trembling, aggression and decreased appetite being the most worrying problems. Isolation and anti-social attitudes are also common
• 68.75% of the studies reviewed demonstrated the anxiolytic effects of CBD
• CBD reduced experimentally-induced anxiety in healthy subjects and reduced anxiety in patients with social anxiety disorders (SAD)
• Systemically administered CBD reduced acute increases in heart rate and blood pressure produced by states of heightened anxiety
• CBD blocked reconsolidation of unpleasant memories in rats and enhanced extinction of fear memories in healthy humans
• Human experimental studies put into evidence CBD’s excellent safety profile and minimal sedative effects

KEY TAKEAWAYS:

• After CBD administration, aggressive behavior towards humans showed a significant decrease 
• Fear and anxiety are a common cause of aggressive conducts in dogs 
• Dogs in the study did not show any of the symptoms referable to CBD intolerance
• CBD treatment did not decrease the activity nor level of attention towards the environment of the dogs studied, as already highlighted for other species 
• The positive outcomes in this defiant environment are promising for more friendlier ones 

KEY TAKEAWAYS:

• 79.2% of the patients exhibited an improvement in anxiety in the 1st month 
• The decrease of anxiety levels was sustained during the rest of the treatment period
• 66.7% of the population experienced less sleep-related problems in the 1st month
• The mean anxiety score dropped from 23.87 to 16.36 in the population whose primary concern was anxiety
• The patients presenting with a primary concern of sleep had a reduction from 13.08 to 9.33 in the mean sleep-problems score

WICHTIGSTE ERKENNTNISSE:

• CBD kann die langanhaltende angstauslösende Wirkung traumatischer Ereignisse verhindern.

• Im Vergleich zur Kontrollgruppe war die Verringerung des Angstverhaltens bei CBD stärker ausgeprägt als bei gängigen Antidepressiva, die zur PTBS-Behandlung eingesetzt werden.

• Die Anti-Stress-Wirkung von CBD könnte von der Aktivierung der Serotonin-Rezeptoren (5HT1A) abhängen; Serotonin trägt zum Wohlbefinden bei, weshalb es oft als Glückshormon bezeichnet wird.

• Die Studie legt nahe, dass CBD ein vorteilhaftes Potenzial für die Behandlung von PTBS besitzt.